RS-OIL - Moria - Alchimia

Release of silicone oil and the off-label use of syringes in ophthalmology

Michela Stocco — Wed, 27 Mar 2019 15:45:52 +0000

Year: 2019

Authors: Gustavo Barreto Melo G. B.; Emerson G. G.; Dias Jr C. S.; Barreto Morais F.; de Souza Lima Filho A.; Ota S.; Eid Farah M.; Büchele Rodrigues E.; Maia M.; Belfort Jr R.

Category: Laboratory science

BMJ Open Opthalmology
doi: 10.1136/bjophthalmol-2019-313823
Online version

This is a: Publication

Background/aims: To assess silicone oil (SO) release by different brands of syringes used for intravitreal injection under different handling conditions.

Methods: Eight syringes were analysed: from the USA, Terumo 0.5 mL, Becton-Dickinson (BD) Tuberculin 1 mL, BD Luer-lok 1 mL, BD Ultra-Fine 0.3 mL and Exel Insulin 0.3 mL; from Germany, Braun Omnifx-F 1 mL and Braun Injekt-F 1 mL and from Spain, BD Plastipak 1 mL.
Theimpact of air, priming the plunger, agitation by ﬂicking and ﬂuid temperature on SO release were assessed by light microscopy. Fourier transform infrared spectroscopy (FTIR) was performed to identify the molecular compound in each syringe.

Results: Five hundred and sixty syringes were analysed.
Terumo 0.5 mL and BD Ultra-Fine 0.3 mL released more SO than all others. BD Luer-lok 1 mL, BD Plastipak and Braun Omnifx-F 1 mL released little SO; BD Tuberculin 1 mL, Exel 0.3 mL and Braun Injekt-F 1 mL released the least SO. Priming the syringe and different temperatures did not signifcantly affect SO release. Agitation by ﬂicking caused a signifcantly higher proportion of samples to have SO droplets and an increased number of oil droplets. Air had an additive effect on the release of oil in the agitation groups. FTIR identifed polysiloxane in all syringes but Injekt-F.

Conclusion: Syringes commonly used for intravitreal injections frequently release SO droplets, especially when agitated by ﬂicking. To avoid unnecessary ocular risks, syringes should not be agitated before intravitreal injection. It is desirable that syringes be manufactured specifcally for ophthalmic use.

L'articolo Release of silicone oil and the off-label use of syringes in ophthalmology proviene da Moria - Alchimia.

Silicone oil flowability rates through a standard 23G vitrectomy system

Michela Stocco — Sat, 28 Jun 2014 15:13:57 +0000

Year 2014

Authors: Haider M.A.; Tayyab H.; Haider S.A.; Javed F.; Rehman M. U.

Pak Armed Forces med J 64(2): 347-51, 2014
Online version

This is a: Publication

Objective: To compare the viscosity of silicone oils made by different manufacturers by comparing the flow rates through a standard 23G millennium vitrectomy system.

Study Design: Quasi experimental study.

Place and Duration of Study: Department of Ophthalmology, Lahore General Hospital Lahore, Pakistan during 2012.

Patients and Methods: Viscosities of silicone oils of 1000 cs and 5000 cs, manufactured by multinational/national manufacturers in Pakistan, were compared. Oils of 1000 cs/5000 cs were placed in 20 ml syringes, marked randomly and placed in water-VVbaths at 250C, to standardize the control environment. Each syringe was then attached to 23G millennium vitrectomy system and time taken to empty 9 ml of oils at pressures of 40 mmHg and 70 mmHg was noted.

Results: Oils of same centistokes manufactured by different manufacturers behaved differently in terms of their flowability and rates of emptying. The emptying times for 1000 cs oils ranged from 112.1 seconds to 144.4 seconds at 40 mmHg and 60.2 to 70.3 seconds at 70 mmHg, whereas corresponding figures for 5000 cs were between 335.7 seconds and 802.0 seconds at 40 mmHg and between 16 9.6 seconds and 348.7 seconds at 70 mmHg. The differences at all levels were statistically significant (p< 0.001).

Conclusion: Silicone oils of similar centistokes behaved differently in terms of their rates of flow through a standard 23G vitrectomy system under standard conditions indicating better standardization of the viscosity of silicone oils available in the market.

L'articolo Silicone oil flowability rates through a standard 23G vitrectomy system proviene da Moria - Alchimia.

Comparison of the antimicrobial effect of heavy silicone oil and conventional silicone oil against endophthalmitis-causing agents

Michela Stocco — Wed, 28 May 2014 15:12:27 +0000

Year: 2014

Authors: Örnek N.; Apan T.; Oğurel R.; Örnek K.

Indian J Ophthalmol. 62(4): 388-391, 2014
Online version

This is a: Publication

Purpose: To conduct an in vitro experimental study comparing the effectiveness of conventional silicone oil and heavy silicone oil against endophthalmitis-causing agents.

Materials and Methods: The antimicrobial activity of conventional silicone oil (RS OIL 5000) and heavy silicone oil (heavySil 1500) was tested. The antinicrobial effects of both silicone oils were determined by the growing capability of the microorganism.

Results: The number of Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans decreased to zero level at the second day of inoculation in heavy silicone oil. In conventional silicone oil, the microorganisms survived longer than in heavy silicone oil.

Conclusion: Heavy silicone oil seems to be more effective than conventional silicone oil against endophthalmitis-causing agents.

L'articolo Comparison of the antimicrobial effect of heavy silicone oil and conventional silicone oil against endophthalmitis-causing agents proviene da Moria - Alchimia.

Ocular tolerance and efficacy of short-term tamponade with double filling of polydimethyloxane and perfluoro-n-octane

Michela Stocco — Sat, 28 May 2011 14:53:52 +0000

Year: 2011

Authors: Zenoni S.; Romano M.R.; Palmieri S.; Comi N.; Fiorentini E.; Fontana P.

Clin Ophthalmol. 2011; 5: 443–449
Online version

This is a: Publication

Abstract: Double filling tamponade was performed in 30 eyes of 30 patients by 30% perfluoro-n-octane and 70% RS-OIL 1000 cS for an average of 23 days, after expanding the vitreous cavity with HPF10 perfluorodecalin.

The follow-up visits were scheduled 1 week, 1 month, and 3 months after surgery. The main outcome measures were visual acuity, intraocular pressure (IOP), PVR reproliferation, and electrophysiological parameters.

The primary success rate was 80% (24/30). Fourteen patients (46.7%) had a postoperative improvement in visual acuity, 12 patients (40.0%) maintained their preoperative visual acuity, and four patients (13.3%) experienced a reduction in visual acuity. In conclusion, our experience with double filling in selected cases of retinal detachment was positive.

No electroretinographic signs of retinal toxicity and a low incidence of PVR reproliferation were observed.

L'articolo Ocular tolerance and efficacy of short-term tamponade with double filling of polydimethyloxane and perfluoro-n-octane proviene da Moria - Alchimia.